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USC-OGP 2-DE database

Two-dimensional polyacrylamide gel electrophoresis database


USC-OGP 2-DE database 
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Searching in 'USC-OGP 2-DE database' for entry matching: P21333




USC-OGP 2-DE database:  P21333


P21333


General information about the entry
View entry in simple text format
Entry nameFLNA_HUMAN
Primary accession numberP21333
integrated into USC-OGP 2-DE database on January 17, 2017 (release 1)
2D Annotations were last modified onJanuary 17, 2017 (version 1)
General Annotations were last modified on April 5, 2017 (version 2)
Name and origin of the protein
DescriptionRecName: Full=Filamin-A; Short=FLN-A; AltName: Full=Actin-binding protein 280; Short=ABP-280; AltName: Full=Alpha-filamin; AltName: Full=Endothelial actin-binding protein; AltName: Full=Filamin-1; AltName: Full=Non-muscle filamin;.
Gene nameName=FLNA
Synonyms=FLN, FLN1
Annotated speciesHomo sapiens (Human) [TaxID: 9606]
TaxonomyEukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo.
References
[1]   2D GEL CHARACTERIZATION
Author 1., Author 2.
Submitted (Mar-2011) to Current
2D PAGE maps for identified proteins
How to interpret a protein

PLATELET_4-5 {PLATELET 4-5}
Homo sapiens (Human)
PLATELET_4-5
  map experimental info
 
PLATELET_4-5

MAP LOCATIONS:
pI=4.82; Mw=91938
pI=4.73; Mw=90967
pI=4.84; Mw=90967
pI=4.80; Mw=90006
pI=4.74; Mw=89529
pI=4.86; Mw=89055
pI=4.89; Mw=87648
pI=4.94; Mw=85806
pI=5.01; Mw=64787
pI=4.91; Mw=27414



PLATELET_4-7 {PLATELET 4-7}
Homo sapiens (Human)
PLATELET_4-7
  map experimental info
 
PLATELET_4-7

MAP LOCATIONS:
pI=5.75; Mw=115322
pI=5.77; Mw=114667
pI=5.80; Mw=114015
pI=5.85; Mw=113367
pI=5.88; Mw=113367
pI=5.91; Mw=112081
pI=5.93; Mw=111444



PLATELET_5-6 {PLATELET 5-6}
Homo sapiens (Human)
PLATELET_5-6
  map experimental info
 
PLATELET_5-6

MAP LOCATIONS:
pI=5.82; Mw=112081
pI=5.85; Mw=110471
pI=5.89; Mw=109410
pI=5.94; Mw=109410
pI=5.92; Mw=108359



UVEAL_MELANOMA_3-10 {UVEAL MELANOMA 3-10}
Homo sapiens (Human)
UVEAL_MELANOMA_3-10
  map experimental info
 
UVEAL_MELANOMA_3-10

MAP LOCATIONS:
pI=8.49; Mw=13705

Cross-references
UniProtKB/Swiss-ProtP21333; FLNA_HUMAN.



2D PAGE maps for identified proteins
  • How to interpret a protein map
  • You may obtain an estimated location of the protein on various 2D PAGE maps, provided the whole amino acid sequence is known. The estimation is obtained according to the computed protein's pI and Mw.
  • Warning 1: the displayed region reflects an area around the theoretical pI and molecular weight of the protein and is only provided for the user's information. It should be used with caution, as the experimental and theoretical positions of a protein may differ significantly.
  • Warning 2: the 2D PAGE map is built on demand. This may take some few seconds to be computed.



External data extracted from UniProtKB/Swiss-Prot
Extracted from UniProtKB/Swiss-Prot, release: 0.0
Entry nameFLNA_HUMAN
Primary accession numberP21333
Secondary accession number(s) E9KL45 Q5HY53 Q5HY55 Q8NF52
Sequence was last modified on January 23, 2007 (version 4)
Annotations were last modified on March 15, 2017 (version 218)
Name and origin of the protein
DescriptionRecName: Full=Filamin-A; Short=FLN-A; AltName: Full=Actin-binding protein 280; Short=ABP-280; AltName: Full=Alpha-filamin; AltName: Full=Endothelial actin-binding protein; AltName: Full=Filamin-1; AltName: Full=Non-muscle filamin;
Gene nameName=FLNA
Synonyms=FLN, FLN1
Encoded onName=FLNA; Synonyms=FLN, FLN1
Keywords3D-structure; Acetylation; Actin-binding; Alternative splicing; Cilium biogenesis/degradation; Complete proteome; Cytoplasm; Cytoskeleton; Deafness; Direct protein sequencing; Disease mutation; Isopeptide bond; Phosphoprotein; Polymorphism; Reference proteome; Repeat; Ubl conjugation.
Copyright
Copyrighted by the UniProt Consortium, see http://www.uniprot.org/help/license. Distributed under the Creative Commons Attribution-NoDerivs License
Cross-references
EMBLX53416; CAA37495.1; -; mRNA
EMBLL44140; AAA92644.1; -; Genomic_DNA
EMBLX70082; CAA49687.1; -; Genomic_DNA
EMBLX70085; CAA49690.1; -; Genomic_DNA
EMBLGU727643; ADU87644.1; -; mRNA
EMBLAK090427; BAC03408.2; ALT_INIT; mRNA
EMBLAB593010; BAJ83965.1; -; mRNA
EMBLBX664723; CAI43197.1; -; Genomic_DNA
EMBLBX936346; CAI43197.1; JOINED; Genomic_DNA
EMBLBX664723; CAI43199.1; -; Genomic_DNA
EMBLBX936346; CAI43199.1; JOINED; Genomic_DNA
EMBLBX936346; CAI43225.1; -; Genomic_DNA
EMBLBX664723; CAI43225.1; JOINED; Genomic_DNA
EMBLBX936346; CAI43227.1; -; Genomic_DNA
EMBLBX664723; CAI43227.1; JOINED; Genomic_DNA
EMBLCH471172; EAW72745.1; -; Genomic_DNA
EMBLCH471172; EAW72746.1; -; Genomic_DNA
CCDSCCDS44021.1; -. [P21333-2]; .
CCDSCCDS48194.1; -. [P21333-1]; .
PIRA37098; A37098; .
RefSeqNP_001104026.1; NM_001110556.1. [P21333-1]; .
RefSeqNP_001447.2; NM_001456.3. [P21333-2]; .
UniGeneHs.195464; -; .
PDB2AAV; NMR; -; A=1863-1956
PDB2BP3; X-ray; 2.32 A; A/B=1863-1956
PDB2BRQ; X-ray; 2.10 A; A/B=2236-2329
PDB2J3S; X-ray; 2.50 A; A/B=2045-2329
PDB2JF1; X-ray; 2.20 A; A=2236-2329
PDB2K3T; NMR; -; A=2427-2522
PDB2K7P; NMR; -; A=1772-1956
PDB2K7Q; NMR; -; A=1954-2141
PDB2MTP; NMR; -; A=2236-2330
PDB2W0P; X-ray; 1.90 A; A/B=2236-2329
PDB2WFN; X-ray; 3.20 A; A/B=1-278
PDB3CNK; X-ray; 1.65 A; A/B=2559-2647
PDB3HOC; X-ray; 2.30 A; A/B=2-269
PDB3HOP; X-ray; 2.30 A; A/B=2-269
PDB3HOR; X-ray; 2.70 A; A/B=2-269
PDB3ISW; X-ray; 2.80 A; A/B=2236-2329
PDB3RGH; X-ray; 2.44 A; A/B=1158-1252
PDB4M9P; X-ray; 1.72 A; A=478-766
PDB4P3W; X-ray; 2.00 A; A/B/C/D/E/F=2152-2329
PDBsum2AAV; -; .
PDBsum2BP3; -; .
PDBsum2BRQ; -; .
PDBsum2J3S; -; .
PDBsum2JF1; -; .
PDBsum2K3T; -; .
PDBsum2K7P; -; .
PDBsum2K7Q; -; .
PDBsum2MTP; -; .
PDBsum2W0P; -; .
PDBsum2WFN; -; .
PDBsum3CNK; -; .
PDBsum3HOC; -; .
PDBsum3HOP; -; .
PDBsum3HOR; -; .
PDBsum3ISW; -; .
PDBsum3RGH; -; .
PDBsum4M9P; -; .
PDBsum4P3W; -; .
ProteinModelPortalP21333; -; .
SMRP21333; -; .
BioGrid108605; 281; .
DIPDIP-1136N; -; .
IntActP21333; 213; .
MINTMINT-118283; -; .
STRING9606.ENSP00000358866; -; .
TCDB8.A.66.1.4; the dystrophin (dystrophin) family; .
iPTMnetP21333; -; .
PhosphoSitePlusP21333; -; .
SwissPalmP21333; -; .
BioMutaFLNA; -; .
DMDM116241365; -; .
OGPP21333; -; .
EPDP21333; -; .
MaxQBP21333; -; .
PaxDbP21333; -; .
PeptideAtlasP21333; -; .
PRIDEP21333; -; .
EnsemblENST00000360319; ENSP00000353467; ENSG00000196924. [P21333-2]; .
EnsemblENST00000369850; ENSP00000358866; ENSG00000196924. [P21333-1]; .
EnsemblENST00000422373; ENSP00000416926; ENSG00000196924. [P21333-2]; .
GeneID2316; -; .
KEGGhsa:2316; -; .
UCSCuc004fkk.3; human. [P21333-1]; .
CTD2316; -; .
DisGeNET2316; -; .
GeneCardsFLNA; -; .
GeneReviewsFLNA; -; .
H-InvDBHIX0017150; -; .
HGNCHGNC:3754; FLNA; .
HPACAB000356; -; .
HPAHPA000368; -; .
HPAHPA001016; -; .
HPAHPA001115; -; .
HPAHPA002925; -; .
MalaCardsFLNA; -; .
MIM300017; gene; .
MIM300048; phenotype; .
MIM300049; phenotype; .
MIM300244; phenotype; .
MIM300321; phenotype; .
MIM304120; phenotype; .
MIM305620; phenotype; .
MIM309350; phenotype; .
MIM311300; phenotype; .
MIM314400; phenotype; .
neXtProtNX_P21333; -; .
OpenTargetsENSG00000196924; -; .
Orphanet2301; Congenital short bowel syndrome; .
Orphanet1864; Congenital valvular dysplasia; .
Orphanet82004; Ehlers-Danlos syndrome with periventricular heterotopia; .
Orphanet323; FG syndrome; .
Orphanet1826; Frontometaphyseal dysplasia; .
Orphanet99811; Neuronal intestinal pseudoobstruction; .
Orphanet2484; Osteodysplasty; Melnick-Needles type; .
Orphanet90650; Otopalatodigital syndrome type 1; .
Orphanet90652; Otopalatodigital syndrome type 2; .
Orphanet98892; Periventricular nodular heterotopia; .
Orphanet88630; Terminal osseous dysplasia - pigmentary defects; .
PharmGKBPA28172; -; .
eggNOGKOG0518; Eukaryota; .
eggNOGCOG5069; LUCA; .
GeneTreeENSGT00660000095431; -; .
HOGENOMHOG000044235; -; .
HOVERGENHBG004163; -; .
InParanoidP21333; -; .
KOK04437; -; .
OMAVQDNEGC; -; .
OrthoDBEOG091G00U5; -; .
PhylomeDBP21333; -; .
TreeFamTF313685; -; .
ReactomeR-HSA-114608; Platelet degranulation; .
ReactomeR-HSA-430116; GP1b-IX-V activation signalling; .
ReactomeR-HSA-446353; Cell-extracellular matrix interactions; .
ReactomeR-HSA-5627123; RHO GTPases activate PAKs; .
SignaLinkP21333; -; .
SIGNORP21333; -; .
ChiTaRSFLNA; human; .
EvolutionaryTraceP21333; -; .
GeneWikiFLNA; -; .
GenomeRNAi2316; -; .
PMAP-CutDBP21333; -; .
PROPR:P21333; -; .
ProteomesUP000005640; Chromosome X; .
BgeeENSG00000196924; -; .
CleanExHS_FLNA; -; .
ExpressionAtlasP21333; baseline and differential; .
GenevisibleP21333; HS; .
GOGO:0015629; C:actin cytoskeleton; IC:BHF-UCL; .
GOGO:0005884; C:actin filament; IEA:Ensembl; .
GOGO:0097440; C:apical dendrite; IEA:Ensembl; .
GOGO:0005911; C:cell-cell junction; IDA:UniProtKB; .
GOGO:0030863; C:cortical cytoskeleton; IEA:Ensembl; .
GOGO:0005737; C:cytoplasm; IDA:UniProtKB; .
GOGO:0005829; C:cytosol; IDA:HPA; .
GOGO:0043198; C:dendritic shaft; IEA:Ensembl; .
GOGO:0070062; C:extracellular exosome; IDA:UniProtKB; .
GOGO:0031012; C:extracellular matrix; IDA:BHF-UCL; .
GOGO:0005576; C:extracellular region; TAS:Reactome; .
GOGO:0005925; C:focal adhesion; IDA:UniProtKB; .
GOGO:0016020; C:membrane; IDA:UniProtKB; .
GOGO:0031523; C:Myb complex; IDA:MGI; .
GOGO:0043025; C:neuronal cell body; IEA:Ensembl; .
GOGO:0005730; C:nucleolus; IMP:CACAO; .
GOGO:0005634; C:nucleus; IDA:UniProtKB; .
GOGO:0048471; C:perinuclear region of cytoplasm; IEA:Ensembl; .
GOGO:0005886; C:plasma membrane; IDA:BHF-UCL; .
GOGO:0030018; C:Z disc; ISS:BHF-UCL; .
GOGO:0051015; F:actin filament binding; IDA:BHF-UCL; .
GOGO:0045296; F:cadherin binding; IDA:BHF-UCL; .
GOGO:0034988; F:Fc-gamma receptor I complex binding; IDA:BHF-UCL; .
GOGO:0001664; F:G-protein coupled receptor binding; IPI:UniProtKB; .
GOGO:0001948; F:glycoprotein binding; IDA:BHF-UCL; .
GOGO:0051020; F:GTPase binding; IPI:UniProtKB; .
GOGO:0044325; F:ion channel binding; IPI:BHF-UCL; .
GOGO:0019900; F:kinase binding; IPI:UniProtKB; .
GOGO:0015459; F:potassium channel regulator activity; IDA:BHF-UCL; .
GOGO:0042803; F:protein homodimerization activity; IDA:BHF-UCL; .
GOGO:0048365; F:Rac GTPase binding; IDA:BHF-UCL; .
GOGO:0017160; F:Ral GTPase binding; IDA:BHF-UCL; .
GOGO:0017048; F:Rho GTPase binding; IDA:BHF-UCL; .
GOGO:0003723; F:RNA binding; IDA:UniProtKB; .
GOGO:0004871; F:signal transducer activity; IMP:UniProtKB; .
GOGO:0031267; F:small GTPase binding; IDA:BHF-UCL; .
GOGO:0008134; F:transcription factor binding; IPI:UniProtKB; .
GOGO:0051764; P:actin crosslink formation; IDA:BHF-UCL; .
GOGO:0031532; P:actin cytoskeleton reorganization; IDA:BHF-UCL; .
GOGO:0007195; P:adenylate cyclase-inhibiting dopamine receptor signaling pathway; IMP:BHF-UCL; .
GOGO:0034329; P:cell junction assembly; TAS:Reactome; .
GOGO:0021987; P:cerebral cortex development; IEA:Ensembl; .
GOGO:0060271; P:cilium assembly; IMP:UniProtKB; .
GOGO:0051220; P:cytoplasmic sequestering of protein; IMP:BHF-UCL; .
GOGO:0045184; P:establishment of protein localization; IDA:BHF-UCL; .
GOGO:0021943; P:formation of radial glial scaffolds; IEA:Ensembl; .
GOGO:0090307; P:mitotic spindle assembly; IDA:MGI; .
GOGO:0042789; P:mRNA transcription from RNA polymerase II promoter; IEA:Ensembl; .
GOGO:0043066; P:negative regulation of apoptotic process; IMP:CACAO; .
GOGO:0042177; P:negative regulation of protein catabolic process; IMP:BHF-UCL; .
GOGO:0043433; P:negative regulation of sequence-specific DNA binding transcription factor activity; IDA:UniProtKB; .
GOGO:0016479; P:negative regulation of transcription from RNA polymerase I promoter; IDA:CACAO; .
GOGO:0030168; P:platelet activation; TAS:Reactome; .
GOGO:0070527; P:platelet aggregation; IMP:UniProtKB; .
GOGO:0002576; P:platelet degranulation; TAS:Reactome; .
GOGO:0043123; P:positive regulation of I-kappaB kinase/NF-kappaB signaling; IMP:UniProtKB; .
GOGO:2001046; P:positive regulation of integrin-mediated signaling pathway; IMP:CACAO; .
GOGO:2000179; P:positive regulation of neural precursor cell proliferation; IEA:Ensembl; .
GOGO:2001224; P:positive regulation of neuron migration; IEA:Ensembl; .
GOGO:1901381; P:positive regulation of potassium ion transmembrane transport; IDA:BHF-UCL; .
GOGO:1900026; P:positive regulation of substrate adhesion-dependent cell spreading; IMP:CACAO; .
GOGO:0042993; P:positive regulation of transcription factor import into nucleus; IMP:UniProtKB; .
GOGO:0034394; P:protein localization to cell surface; IDA:BHF-UCL; .
GOGO:0072659; P:protein localization to plasma membrane; IDA:BHF-UCL; .
GOGO:0050821; P:protein stabilization; IMP:BHF-UCL; .
GOGO:0043113; P:receptor clustering; IDA:BHF-UCL; .
GOGO:0030334; P:regulation of cell migration; IDA:UniProtKB; .
GOGO:1905000; P:regulation of membrane repolarization during atrial cardiac muscle cell action potential; IC:BHF-UCL; .
GOGO:1905031; P:regulation of membrane repolarization during cardiac muscle cell action potential; ISS:BHF-UCL; .
GOGO:0071526; P:semaphorin-plexin signaling pathway; IGI:WormBase; .
GOGO:0044319; P:wound healing; spreading of cells; IDA:UniProtKB
CDDcd00014; CH; 2; .
Gene3D1.10.418.10; -; 2; .
Gene3D2.60.40.10; -; 24; .
InterProIPR001589; Actinin_actin-bd_CS; .
InterProIPR001715; CH-domain; .
InterProIPR017868; Filamin/ABP280_repeat-like; .
InterProIPR001298; Filamin/ABP280_rpt; .
InterProIPR028559; FLN_A; .
InterProIPR013783; Ig-like_fold; .
InterProIPR014756; Ig_E-set; .
PANTHERPTHR11915:SF348; PTHR11915:SF348; 1; .
PfamPF00307; CH; 2; .
PfamPF00630; Filamin; 23; .
SMARTSM00033; CH; 2; .
SMARTSM00557; IG_FLMN; 24; .
SUPFAMSSF47576; SSF47576; 1; .
SUPFAMSSF81296; SSF81296; 24; .
PROSITEPS00019; ACTININ_1; 1; .
PROSITEPS00020; ACTININ_2; 1; .
PROSITEPS50021; CH; 2; .
PROSITEPS50194; FILAMIN_REPEAT; 24; .



USC-OGP 2-DE database image


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Database constructed and maintained by Angel Garcia, using the Make2D-DB II package (ver. 3.10.2) from the World-2DPAGE Constellation of the ExPASy web server

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